Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
نویسندگان
چکیده
منابع مشابه
Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconstitution of p18(INK4C) in GBM cells null for both p16(INK4A) and p18(INK4C) resulted in impaired cell-cycle progression and tumorigenic potential. Conversely, RNAi-medi...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2008
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2008.02.010